Oxford University Press's
Academic Insights for the Thinking World

Lactate: the forgotten cancer master regulator

In 1923 Nobel laureate Otto Warburg observed that cancer cells expressed accelerated glycolysis and excessive lactate formation even under fully oxygenated conditions. His discovery, which is expressed in about 80% of cancers, was named the “Warburg Effect” in 1972 by Efraim Racker. The Warburg Effect in cancer and its role in carcinogenesis has been neither understood nor explained for almost a century.

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Marcel Duchamp’s most political work of art

A hundred years ago last month, two of the most influential historical events of the twentieth century occurred within a span of three days. The first of these took place on 6 April 1917, when the United States declared war on Germany and, in doing so, thrust the USA into a leading role on the world stage for the first time in its history.

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Lost in time: the El Cortez hotel and casino

On a sticky afternoon in June of 2015 I, with friend and photographer, Matilda Temperley, drove through downtown Las Vegas and into the driveway of the El Cortez Hotel and Casino. The midday sun exposed some rust on the hotel’s neon signage as well as a missing light bulb on the giant red, rotating high healed shoe, which framed an advertisement for $10.95 Prime Rib at the hotel’s diner.

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Prime numbers and how to find them

Prime numbers have now become a crucial part of modern life, but they have been fascinating mathematicians for thousands of years. A prime number is always bigger than 1 and can only be divided by itself and 1 – no other number will divide in to it. So the number 2 is the first prime number, then 3, 5, 7, and so on. Non-prime numbers are defined as composite numbers (they are composed of other smaller numbers).

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Did you know these 10 fascinating facts about museums?

Collections of art, scientific instruments, historical relics, and peculiarities have attracted the curiosity and imaginations of people around the world since ancient times. The museum as an institution developed in antiquity and evolved over the years to encompass and celebrate all aspects of human society, science, art, and history. Museums are vital to the study […]

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Adult ADHD: myths and reality

One out of every 5-10 adult psychotherapy clients probably has attention deficit/hyperactivity disorder (ADHD). Key studies and writings emerged in 1995 supporting the idea of adult ADHD, but it took many years of reading and research to confidently recognize and appropriately treat adult ADHD. It continues to be underrecognized by mental health clinicians, even when clients with ADHD are already in treatment for other mental illnesses, and considerable misinformation is circulated.

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David Hume: friendships, feuds, and faith

Who exactly was David Hume? He was a Scottish historian and philosopher (best known today for his radical empiricism), who prided himself on his reputation as a man of the utmost moral character.

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What kind of encore do you want?

The bonus years of extended life expectancy are not coming at the end of life, adding to years of disability and decline, but rather, in the expanding period of health and vitality around the 60s and 70s, but coming earlier or later for some. The new longevity is advantageous to individuals, but costly to society. It is distinct from both full-time career employment and full-time retirement leisure.

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Does foreign meddling in elections matter?

Ever since the exposure of the covert Russian intervention in the 2016 US election, questions have arisen about the effects that foreign meddling of this type may have. Before these events transpired, I had begun studying the wider question, investigating whether partisan electoral interventions by the US and USSR/Russia usually effect the election results.

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At bay: where is that bay?

To keep somebody or something at bay means “to keep a dangerous opponent at a distance; to hold off, ward off a disaster, etc.” The very first interpreters of this idiom guessed its origin correctly. They stated that bay here means “to bark” and that at bay refers to hunting.

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Is child poverty in rich countries exacerbated by the economic crisis?

The 2008 financial crisis triggered the first contraction of the world economy in the post-war era. Amid falling wages and increasing unemployment, government capacity to address worsening social conditions was often constrained by mounting deficits, with social protection systems under threat when they were most needed. Children and young people, already at a greater risk of poverty than the population as a whole.

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Henry Wadsworth Longfellow on birds, poetry, and immigration

On 26 February this year, Henry Wadsworth Longfellow, the most popular poet America has ever had, turned 210. The lines from Longfellow everyone remembers, often without knowing who actually wrote them (“into each life a little rain must fall”; “Let us, then, be up and doing”; “Each thing in its place is best”), point to an author who wanted to help us live our lives, not exactly change them.

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What the WannaCry attack means for all of us

As the aftershocks of last week’s big “WannaCry” cyberattack reverberate, it’s worth taking a moment to think about what it all means. First, ransomware is a growing menace, and this may be the case that gets it global attention. The idea behind ransomware is simple: no one is willing to pay as much as you for your data. Instead of copying critical data and trying to sell it to others, ransomware authors will simply deny their target access until payment is made.

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