Oxford University Press's
Academic Insights for the Thinking World
Jimmie C. Holland, MD, internationally recognized as the founder of the field of Psycho-oncology, died suddenly on 24 December 2017 at the age of 89. Dr. Holland, who was affectionately known by her first name, “Jimmie,” had a profound global influence on the fields of Psycho-oncology, Psychosomatic Medicine, and Oncology.
The 200th anniversary of James Parkinson’s seminal Essay on the Shaking Palsy gives cause for commemoration and reflection. Parkinson’s astute observation and careful description of only six patients led to one of the earliest and most complete clinical descriptions of Parkinson’s disease. With the concept of a syndrome still not fully realised, Parkinson was among the first writers to unify a set of seemingly unrelated symptoms into one diagnosis.
Tier 1 genomic applications, backed by strong evidence of their clinical utility, support population screening to identify those at heightened risk for inherited cancers and cardiovascular disease. While accounting for less than 10% of the population, these individuals and families account for disproportionate morbidity and mortality and can benefit from targeted prevention efforts.
The human brain is a wonder and a marvel. At the same time, it is enigma and frustration. Given all it has accomplished, it continues to perplex. This is why I became a neurologist. For me, combining the apex of all organic structures with the vast unknown of cerebral neuroscience produces a daily wonder that is worth dedicating a life’s work to. To that end, I find myself somewhere over the North Pole hurling towards PyongChang, South Korea.
In April 2003, researchers from the Human Genome Project published the result of their painstaking work; a complete sequencing of the human genome. This ground-breaking feat has ushered in the current “post genomic” era of medicine, whereby medical treatment is becoming increasingly personalised towards an individual’s specific lifestyle and genetic makeup.
In Finland, sauna bathing has been practiced for centuries, either for pleasure, but more importantly also for reasons of hygiene and maintenance of health. Many curative and magical effects have been attributed to its practice and seldom has it been thought to cause any disease. The benefit of the sauna lies in its increased temperatures. Heat therapy has many benefits for human physiology.
Short sleep is common in teens, particularly on school nights, with a majority obtaining less than the eight to ten hours recommended. Many factors contribute to insufficient sleep during adolescence including increased social and academic demands, bedtime autonomy, the use of electronics, and early school start times coupled with a biological and behavioral tendency to stay up later.
For 15 years I have counseled patients about what it means to carry a mutation in a gene that can lead to a higher risk of developing cancer. Hundreds of times I have said, “A mutation was found.” Our patients have different mutations in different genes. They come from different parts of the world. They speak a variety of languages, and bring their cultural heritage and expectations to our sessions.
The body mass index (BMI) is a crude but useful measure of how heavy someone is for their weight. It consists of your weight in kilograms, divided by the square of your height in metres. Guidelines suggest that a BMI between 18.5 and 25 is healthy for most people. You are classed as overweight if it is 25-30 and obese if it is more than 30.
The concept of creativity is imbued with two contradictory notions. The first notion usually considers that a creative production is the result of high-level control functions such as inhibition, mental manipulation, or planning. These functions are known to depend on the anterior part of the brain: the prefrontal cortex.
World Cancer Day is on the 4th of February. The purpose is to increase global awareness and get as many people talking about the disease as possible. Essentially, unite people from all around the world in the fight against cancer—and with worldwide incidence set to increase to 21.7 million by 2030, the fight is now. 2018 is the last in the three year ‘We Can. I can.’ campaign
To mark the release of Vanishing Bone, in Part One of our Q&A with Dr. William H. Harris we discussed the fascinating story of how he came to identify, and later cure, the severe bone destruction affecting individuals who had undergone total hip replacement surgery. In this second interview, Dr. Harris reflects on his remarkable career; including what inspired him to pursue orthopaedic surgery, how he balances his two roles as a surgeon and clinician-scientist, and his advice for aspiring surgeons.
In early 2011, Jon Underwood decided to develop a series of projects about death – one of which was to focus on talking about death. Jon read about the work of Bernard Crettaz, the pioneer of Cafes Mortéls which were themselves inspired by the cafes and coffeehouses of the European Enlightenment. Motivated by Bernard’s work, Jon immediately decided to use a similar model for his own project, and Death Cafe was born.
Death and dying surrounds us, yet many of us see it as an uncomfortable taboo subject. As part of a series of articles on encouraging an open dialogue around death and dying, we asked various healthcare professionals, academics, and members of the public who have experienced palliative care the following question: How important is it that we as a society are open to discussing death and dying?
It has been known for centuries that bacteria tend to adhere to solid surfaces, forming a slimy and slippery layer known as biofilm. Bacterial biofilms are complex microbial communities protected by an extracellular matrix composed of polysaccharides, proteins, and nucleic acids. The extracellular matrix improves biofilm cohesion and its adhesion to surfaces.
When orthopaedic surgeon, Dr. William H Harris discovered massive bone destruction around a total hip replacement that he had implanted, he was startled and dismayed. In fact, he had identified a new condition, “periprosthetic osteolysis”, which came to be the leading factor in failure of total hip replacement (THR) surgery. While THR surgery dramatically reversed severe arthritis of the hip, the same operation simultaneously created a relentless “particle generator” in the body.