Oxford University Press's
Academic Insights for the Thinking World

Celebrating 40 years of the Journal of Antimicrobial Chemotherapy

“The knowledge of the capabilities of antibiotics is still essential to control infections which nowadays are more complex and often occur in patients whose defences are compromised by other forms of medical and surgical treatment” wrote Professor J. D. Williams in his first Editorial in the Journal of Antimicrobial Chemotherapy (JAC) in 1975.

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Lead poisoning of Flint, Michigan—penny wise, pound foolish, and criminal

The tragedy of children poisoned by lead-contaminated water in Flint, Michigan is not an isolated incident. More than 11 counties in New Jersey have children with higher lead levels than those of Flint. Since 2008, drastic cuts in funding for public health programs across the board have slashed programs to educate parents and pediatricians to test young kids for lead poisoning or test water for its residues.

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Why ‘ageism’ is bad for your health

According to research conducted by Levy, Slade, Kunkel, and Kasl in 2002, the average lifespan of those with high levels of negative beliefs about old age is 7.5 years shorter than those with more positive beliefs. In other words, ‘ageism’ may have a cumulative harmful effect on personal health. But what is ageism – and what is its impact, both for society and healthcare?

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The importance of long-term marriage for health and happiness

Each year around Valentine’s Day, a new crop of romantic comedies hit the silver screen. Viewers wait in anticipation for the on-screen couple’s first kiss, or the enviably lavish wedding. But what happens to that couple, many decades after the first kiss or exchange of rings? Recent research shows that long-married couples exchange love and emotional support, but also regularly engage in spats or minor conflicts which affect older adults’ health in both expected and surprising ways.

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Why is addiction treatment so slow to change?

The US taxpayers fund the overwhelming majority of addiction research in the world. Every year, Congress channels about $1 billion to the National Institute on Drug Abuse (NIDA). An additional almost $0.5 billion is separately given to the National Institute on Alcohol Abuse and Alcoholism (NIAAA), my own workplace for the past decade.

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Another unpleasant infection: Zika virus

Over two years ago I wrote that “new viruses are constantly being discovered… Then something comes out of the woodwork like SARS which causes widespread panic.” Zika virus infection bids fair to repeat the torment. On 28 January 2016 the BBC reported that the World Health Organization had set up a Zika “emergency team” as a result of the current explosive pandemic.

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Seven reasons why your medications are not working properly

What happens when medication doesn’t bring your condition under control? Usually, it’s not just one single issue but various factors that contribute to the problem. Your doctor will work to figure out why–and from there, create a new plan of attack. Finding the right combination of medications may require some trial and error.

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Nils Alwall: The quiet, unassuming Swede

During the night, between 3rd and 4th September 1946, things were stirring in the basement of the internal medicine department, at the university hospital of Lund, Southern Sweden. A 47-year-old man had been admitted for treatment. His main problem was uraemia (urea in the blood), but he was also suffering from silicosis (a lung disorder), complicated by pneumonia.

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The truth behind the restaurant industry [quiz]

While the common image of a “restaurant employee” is the server, there are others in the restaurant industry who also face the hardships of working in the restaurant industry: discrimination, low wages, and lack of benefits. All these contribute to a dark side of the restaurant industry, and some restaurants are fighting to change the status quo. Do you know the truth behind the restaurant industry?

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World Cancer Day – a reading list

Every year, World Cancer Day aims to save millions of preventable deaths, by raising awareness and education about the disease. Whether you are a health professional, a carer, patient, policy-maker, or simply looking to get involved – we can all to our bit to help reduce the global burden of cancer.

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Metastatic cells colonize implantable scaffold in mice

Cancer treatment’s biggest failings occur in the metastatic setting, when metastatic cells escaping from the primary tumor colonize and attack critical organs. Much about how cells colonize distant tissues as opposed to remaining in the primary tumor or in circulation without settling in one place remains unknown. But a new bioengineered device could offer insights.

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The Cancer Moonshot

Announced on January 13th by President Obama in his eighth and final State of the Union Address, the multi-billion dollar project will be led by US Vice President, Joe Biden, who has a vested interest in seeing new cures for cancer. Using genomics to cure cancer is being held on par with JFK’s desire in 1961 to land men on the moon.

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The Zika virus: a “virgin soil” epidemic

First isolated in Uganda in 1947, this normally mild, non-fatal mosquito-born flavivirus infection is characterized by transient fever, joint pain and malaise. The current explosive Zika virus epidemic in the Americas is, however, causing great concern because of what looks to be a sudden, dramatic increase in the incidence of microcephaly (small brain/head size) in newborns.

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The evolution of breathing tests

If a person is experiencing difficulty breathing comfortably, the chances are that the difficulty stays with them no matter what they’re doing, be it sitting, standing, or walking. So it’s not surprising that conventional scans or breathing tests, carried out with the patient lying on a couch or sitting in a chair, don’t always tell us what the problem is.

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Landmarks in the study of rheumatology

From experiments with steroids, to placebos, and genome-wide studies, we take a look back at over two centuries of rheumatology studies. Rheumatology involves the study of any disorders of the joints, muscles, and ligaments – including such debilitating conditions as rheumatism and arthritis.

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