Oxford University Press's
Academic Insights for the Thinking World

A conversation with a widow’s nervous system

My late husband Gene Cohen is known as one of the founders of both geriatric psychiatry and the creative aging movement. He was always talking, writing, and educating about brain plasticity and the changes that took place as we age into our wisdom and creative potential.

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Immunogenic mutations: Cancer’s Achilles heel

In the 1890s, a surgical oncologist named William Coley first attempted to harness the immune system to fight cancer. He injected a mixture of bacterial strains into patient tumors, and occasionally, the tumors disappeared. The treatment was termed “Coley’s Toxins,” and although treatments only rarely resolved cancer cases, it launched a long investigation into anti-tumor immunity.

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Brain waves, impulse control, and free will

In a delightful passage of his book Elbow Room, the philosopher Dan Dennett writes “The first day I was ever in London, I found myself looking for the nearest Underground station. I noticed a stairway in the sidewalk labeled ‘SUBWAY’, which in Boston is our word for the Underground, so I confidently descended the stairs and marched forth looking for the trains.”

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Why we need female brains in CTE research

US soccer player Brandi Chastain became a household name through her outstanding play in the 1999 Women’s World Cup. She scored the championship-winning goal in the unforgettable final shoot-out in front of the world and 90,000 fans at the Rose Bowl in Pasadena, California.

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How filling the Supreme Court vacancy will affect public health

Who is selected to fill the vacancy on the Supreme Court will profoundly affect key public health issues, including gun control, access to reproductive health services, and climate change. In recent years, the Court has ruled, usually by 5-to-4 decisions, on these issues and will likely continue to do so by narrow margins.

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Leap day, giant viruses, and gene-editing

2016 is a leap year. A leap year, or intercalary year, is a year with an extra day inserted to keep pace with the seasons. In the Gregorian calendar this falls every four years on Feb 29th. On Leap Day this year a wonderful piece of science was published about an equally rare part of nature – giant viruses.

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Saladin’s Islamic State

Aleppo, Mosul, Tikrit, Acre… Until just a few years ago, these names meant little to the average American. Now they are all too familiar, as are the atrocities being committed there in the name of religion. Eight hundred years ago the situation in that region was much the same, except then, Christians were committing acts of cruelty no less numerous or shocking than Muslims.

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FEMS Microbiology Letters

Towards a global approach to combat antibiotic resistance

The eradication of infectious diseases in the 20th century is arguably one of the most important achievements in modern medicine. The treatment of such illnesses as tuberculosis, leprosy, syphilis, cholera, pertussis, or diphtheria with antibiotics have reduced suffering, increased hygiene, enormously improved lifestyle, and skyrocketed life expectancy around the globe – particularly in developed countries.

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The true meaning of cell life and death

Two hundred years ago, William Lawrence blew the roof off the Hunter Lecture Series at the Royal College of Surgeons by adding the word “biology” to the English language to discuss living physiology, behavior, and diversity as a matter of gunky chemistry and physics, sans super-added forces.

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E-cigarettes may lead to youth tobacco use

This past summer, the Atlanta suburb of Roswell, Georgia, banned use of e-cigarettes and vapor pens in public parks. Officials enacted the restriction not because of rampant use of the devices in the city but, as mayor Jere Wood said, to “get ahead of the curve. Smokeless device use is soaring. To fulfill demand, vapor shops are popping up all over.

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Cancer is no moonshot

A tired old elephant hunched in the room as President Obama announced the launch of a new moonshot against cancer during his State of the Union address a month ago. We’ve heard that promise before. On 23 December 1971, when President Nixon first declared a national war on cancer, he also based his conviction on the successfully completed moonwalk.

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The perils of salt

The Amazonian Yanomami Indians famously manage on only 50 mg (1 mmol) of sodium chloride per day, while in more developed societies, we struggle to keep our average intake below 100 times that level.

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Keep your friends close… Really?

Who has never been embarrassed by a close other? Imagine you and your best friend dress up for the opera, both of you very excited about this spectacular event taking place in your home town. It is the premiere with the mayor and significant others attending. You have a perfect view on the stage and it seems a wonderful night.

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Should primary schools be responsible for childhood obesity prevention?

In most developed (and many developing) countries, childhood obesity has become much more common over the last few decades, and it is now regarded as one of the most serious global public health challenges of the 21st century. In England, one in five 4-5-year-olds are now overweight or obese, rising to one in three 10-11-year-olds.

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A short history of the mosquito that transmits Zika virus

Question: What do Napoléon Bonaparte, Walter Reed, the Panama Canal, and the Zika virus all have in common? Answer: The Aedes aegypti mosquito. Although its official common name, according to the Entomological Society of America (ESA), is the “yellowfever mosquito,” Aedes aegypti is also the primary vector of dengue, chikungunya, and the Zika virus.

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