Oxford University Press's
Academic Insights for the Thinking World

What is cancer drug resistance? Q&A with Dr Maurizio D’Incalci

One of the biggest obstacles in treating cancer is drug resistance. There are still many unanswered questions about the genomic features of this resistance, including different patient responses to therapy, the role drug resistance plays in the relapse of tumours, and how cancer treatments in the future will combat drug resistance.

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Why e-cigarettes have an image problem

E-cigarettes have an image problem. I mean this in two different ways. They are still seen as controversial products, often featuring in dramatic stories about battery explosions or toxic substances. Most of these stories play on public fears, exaggerate their claims, and are unhelpful for fostering a constructive public debate. But more generally, e-cigarettes have an image problem in that no one agrees on what they represent.

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Uterus transplants: challenges and potential

The birth of a healthy child in Sweden in October, 2014 after a uterus transplant from a living donor marked the advent of a new technique to help women with absent or non-functional uteruses to bear genetic offspring. The Cleveland Clinic has now led American doctors into this space, performing the first US uterine transplant in February, 2016

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Imagining zombies

Understanding the relationship between the mind and the body remains one of the most vexed problems in philosophy, cognitive science, and neuroscience. Physicalism has not reigned unchallenged, however. A number of arguments have been raised which promote dualism in its place — the view that fundamentally, the mind and body are separate.

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Putting oral history on the map

Oral history has always been concerned with preserving the voices of the voiceless, and new technologies are enabling oral historians to preserve and present these memories in new and exciting ways. Audio projects can now turn to mapping software to connect oral histories with physical locations, bringing together voices and places.

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African studies: a reading list

frican Studies focuses on the rich culture, history and society of the continent, however the growing economies of African countries have become an increasingly significant topic in Economic literature. This month, The Centre for the Study of African Economies annual conference is taking place in Oxford. To raise further awareness of the growing importance of the study of African economics, we have created this reading list of books, journals and online resources that explore the varied areas of Africa and its economy.

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Adding a new dimension to the early chemistry of the solar system

What was our solar system composed of right after its formation? Using sophisticated computer simulations, researchers from France and Australia have obtained new insights into the chemical composition of the dust grains that formed in the early solar system which went on to form the building blocks of the terrestrial planets.

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Exposures from the dark side

Julian Assange is an unusual figure in the world of hacktivism. He embraced his notoriety as leader of Wikileaks, and on 4 February 2016, he appeared on the balcony of the Ecuadorian embassy holding a copy of a UN panel report that declared that he has been “arbitrarily detained” while avoiding extradition to Sweden for alleged rape for almost six years (British and Swedish prosecutors still seek to detain him).

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New frontiers in evolutionary linguistics

Our mother tongues seem to us like the natural way to communicate, but it is perhaps a universal human experience to be confronted and confused by a very different language. We can’t help but wonder how and why other languages sound so strange to us, and can be so difficult to learn as adults. This is an even bigger surprise when we consider that all languages come from a common source.

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Immunogenic mutations: Cancer’s Achilles heel

In the 1890s, a surgical oncologist named William Coley first attempted to harness the immune system to fight cancer. He injected a mixture of bacterial strains into patient tumors, and occasionally, the tumors disappeared. The treatment was termed “Coley’s Toxins,” and although treatments only rarely resolved cancer cases, it launched a long investigation into anti-tumor immunity.

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Long-term effects of slave exporting in West Africa

History matters. Historical events can sometimes have consequences that last long after the events have finished. An important part of Africa’s past is its history of slave exporting. Although Africa is not unique to the trading of slaves, the magnitude of slave exporting rose to levels not previously experienced anywhere else in the world.

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Brain waves, impulse control, and free will

In a delightful passage of his book Elbow Room, the philosopher Dan Dennett writes “The first day I was ever in London, I found myself looking for the nearest Underground station. I noticed a stairway in the sidewalk labeled ‘SUBWAY’, which in Boston is our word for the Underground, so I confidently descended the stairs and marched forth looking for the trains.”

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Q&A with social worker Anderson Al Wazni

March is National Social Work Month. This year’s theme is Forging Solutions Out of Challenges. One social worker who is forging ahead is Anderson Al Wazni of Raleigh, NC. Anderson’s research and passion explores Muslim women’s feminist identity and empowerment in her community and beyond. We sat down with Anderson to discuss her role as a social worker and future plans.

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Jacob Zuma’s endgame and the state of South African politics

It is possible that events in recent months may have signalled the beginning of the end for South Africa’s president, Jacob Zuma. True, Zuma has proved to be a resilient politician in the face of relentless criticism, ridicule and scandal, which began long before he came to power and premature predictions of his demise abound.

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