Immunotherapy is a form of treatment to improve the natural ability of the immune system to fight diseases and infections, with immuno-oncology (IO) focusing on combatting cancer specifically. Novel immunotherapies are a possible solution for cancers that don’t respond to standard cancer treatments, either as standalone or in combination therapy.
Over the last 100 years, the world, people, and our society have changed beyond measure. So have diseases, and we are now almost 75 years into the first ever age where cure of disease, successful organ transplants and near complete recovery from trauma has been possible. Despite all of this change, however, medical school curricula have hardly changed in a hundred years.
We all know that we start with baby teeth which fall out and are replaced with adult teeth, but do we really know why? Where do our baby teeth come from in the first place? This adapted extract below from the Oxford Handbook of Integrated Dental Biosciences highlights how our teeth form, why they erupt through our gums when they do, what causes teething pains, and when baby teeth should begin to appear.
The story on the front page of The Sunday Times on 3 June 2018 pulled no punches. Headlined “Revealed: plans for Doomsday Brexit”, it reported on leaked government papers planning for a “no deal” Brexit scenario. They warned that the port of Dover could collapse on day one of exiting the EU, with major food shortages within a few days and medicines shortages within two weeks.
Staying on top of multiple chronic illnesses such as diabetes and heart failure can be a challenge for even the most well-resourced patient – imagine doing so while battling homelessness and schizophrenia. The result is often frequent trips to the emergency department and the hospital. Not surprisingly, many healthcare systems have started implementing programs to address the needs of these patients.
Surgical cases dramatized in popular culture are loosely based on reality, but surgery is decidedly less glamorous on a daily basis. Before embarking on my own surgery training, I mentally prepared myself for the long hours and expected demands of caring for sick surgical patients, but looking back, the lessons I remember most came from small, quiet, and often unexpected moments.
In recent years the language used to describe what constitutes good end-of-life care has changed. ‘Shared-decision making’, ‘patient autonomy’, ‘choice’ and ‘advance care planning’ have become buzzwords. This is to be welcomed, of course, but has the sector really changed in practice? According to several policy reports, in addition to feedback from people who use end-of-life services, not particularly.
Over 80,000 children and adolescents in the United States live with inflammatory bowel diseases (IBD), which includes Crohn’s Disease and Ulcerative Colitis. These are chronic autoimmune diseases that cause inflammation in the gastrointestinal tract.
What is social entrepreneurship? In essence, it’s about using the tools of entrepreneurship—opportunity, resourcefulness, innovation—to address stubborn social and environmental problems. A defining feature of social entrepreneurship is the concept of systemic change; that is, change that addresses the underlying social, political, and economic forces that conspire to exclude the poor and marginalised from the opportunities that many of us take for granted.
According to the Australian euthanasia activist Philip Nitschke, to choose when you die is “a fundamental human right. It’s not just some medical privilege for the very sick. If you’ve got the precious gift of life, you should be able to give that gift away at the time of your choosing.” This view combines two extreme standpoints in the debate on euthanasia and assisted suicide.
On the day after the horrific shooting that claimed the lives of 17 students at Stoneman Douglas High School in Parkland, Florida, the local state representative predicted what would happen next. “Nothing.”
This year is the centenary of the Spanish influenza pandemic of 1918. However, it was only by 2010 that the industry had started universal flu vaccine trials, following the Swine flu pandemic in 2009. Explore the last hundred years of flu, as we mark the Spanish flu centenary, from the four major pandemics to the medical advances along the way, with this interactive timeline.
Many individuals in the United States will receive a cancer diagnosis this year. Such a diagnosis is upsetting to those who receive it and overwhelming to those—relatives or friends—who love them. Cancer is rarely experienced in isolation.
The stroboscope is an ingenious device of rapidly flashing lights that allows engineers and scientists to freeze motion and capture brief slices of time. The resulting image is akin to examining a single frame of a motion picture that provides a sharp image, albeit one without context and with neither past nor future. This is now, sadly, an apt metaphor for contemporary clinical encounters.
It is commonly said that necessity is the mother of invention, and this was certainly the case at UCLA Medical Center in 2014 . Howard Broadman, then aged 64 and a retired judge from San Diego County, California, was concerned that his grandson, Quinn Gerlach, would be unable to secure a transplant kidney when he needed one. And so began the first “voucher system” for kidney procurement.
For millennia, medicine has been applied towards three main areas of the human condition: the mind, the body, and the spirit. Traditional Chinese medicine was similar to ancient Indian medicine in that it sought to create a holistic approach to treating illness, and recognised the contributions of psychological and social aspects in disease management.