Oxford University Press's
Academic Insights for the Thinking World

  • Author: Krista Power

The Journal of Gerontology

What do we know about the effect of gut microbiome in diet and exercise on brain health?

The gastrointestinal tract is one of the most densely populated microbial habitats on earth, containing more cells than those that make up the human body and 150 times the number of genes than exist within the human genome. An unhealthy gut environment is characterized by a reduction in the diversity of bacteria, leading to gut barrier permeability and the release of endotoxins into the blood stream that negatively impacts the brain.

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